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Epigenetic Mechanisms Governing Nrf2 Expression and Its Role in Ferroptosis
Current preclinical research on therapeutic strategies and human clinical trials can be divided into drugs that target the primary cause, i.e., loss-of-function mutations in MECP2 , and drugs that target downstream consequences, including neurotransmitter receptor systems, neurotrophins, and their intracellular signaling pathways (Tables 3, 4)
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Dimedone-based probes satisfy the former criteria, but do so with moderate chemical reactivity
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