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Additionally, the hypoxyprobe staining results indicated that hypoxia in the muscles and hippocampal CA3 region significantly increased in eBpgm –/– and Bpgm f/f mice with age, that hypoxia in the muscles and hippocampal CA3 sections was significantly greater in 4- and 15-month-old eBpgm –/– mice than that in age-matched Bpgm f/f mice (Fig