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For example, WD-associated anxiety-like behavior is accompanied by increased expression of 5HT-r1a and GABAa alpha2 receptor subunit in the ventral HPC (Peleg-Raibstein et al., 2012), a region where BDNF levels correlate with the magnitude of anxiety-like behavior in the EPM task in wildtype mice (Yee et al., 2007)

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Recent clinical research has increasingly pointed to a profound cellular energy crisis driven by severe oxidative stress and the depletion of a critical molecule called glutathione