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The balance of the different CRP isoforms, monomeric (mCRP) or native pentameric (nCRP) within the plaque determines the preponderance of a proinflammatory or anti-inflammatory effect, respectively ( via phosphorylcholine binding and seems to be, as mCRP, proinflammatory (Figure 7)

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AMX0035 had shown significant slowing of disease progression and prolonged survival (40)