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The biological activity of the peptide could be lost

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Knockout mutants for cytosolic NADP-isocitrate dehydrogenase (At1g65930) do not show a significant difference in whole leaf NADP + :NADPH ratios, but the absence of this enzyme does modify the GSH:GSSG ratiounder conditions of increased H 2 O 2 availability (Mhamdi et al., 2010b)