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This is mainly due to the functioning of the pineal gland deteriorating with increased age and a reduction of the hormone circadian rhythm amplitude

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These are known as extraintestinal manifestations : Joint pain and swelling (arthritis) Skin conditions such as erythema nodosum (tender red bumps, usually on the shins) Eye inflammation (uveitis, episcleritis) Liver inflammation (a condition called primary sclerosing cholangitis, in a small number of patients) Reduced bone density over time If you notice new or worsening symptoms — especially blood in stools, persistent fever, weight loss, severe abdominal pain, or signs of obstruction — contact your gastroenterology team rather than waiting for your next routine appointment