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The MNCs-mediated PDT treatment led to persistent production of free radicals by promoting the polarization of macrophages into pro-inflammatory M1 phenotype, electron-hole dissociation efficacy, and stimulating a systemic immunological response against the tumor (287) However, concurrent adaptive immune resistance was observed with the MNCs-mediated PDT treatment, which was typified by increased expression of PD-L1 on tumor tissue, macrophages, and DCs
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Auditory stress resulted in enlarged ovaries, persistent estrus, and follicular hematomas in female rats and rabbits