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In addition to non-coding RNAs, RBPs (RNA-binding proteins) are also able to regulate GPx4 expression, e.g., Staphylococcal nuclease SND1 (structural domain-containing protein 1) promotes the degradation of GPx4 by destabilizing HSPA5 (heat shock protein family A member 5) mRNAs and repressing HSPA5 expression to promote ferroptosis of osteoarthritic chondrocytes

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Nature 624 (7992), 645–652