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For the B group, Vlieg-Boerstra [428] did not find any influence of folate or vitamin B12 supplementation on the incidence of RTIs

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Inflammatory mediators, ferroptosis inducers, mechanical overloading, and iron overload increase the accumulation of ROS and lipid peroxidation in chondrocytes, which can lead to chondrocytes ferroptosis and might contribute to the pathogenesis

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