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[DOI] [PMC free article] [PubMed] [Google Scholar] 114.Tang Y., Yang Q., Lu J., Zhang X., Suen D., Tan Y., Jin L., Xiao J., Xie R., Rane M., et al

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It was proposed that following chronic morphine, β- arrestin2-dependent regulation of MOR is enhanced, slowing recovery from desensitization, thereby shifting the equilibrium between active and desensitized receptors to an accumulation of desensitized MOR, resulting in MOR tolerance (Dang et al., 2011