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But rapamycin has uncertain efficacy and potential adverse effects (Moghadamnia et al., 2024)

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155 Interestingly, another study demonstrated that NK cells can promote liver regeneration by scavenging extracellular adenosine triphosphate (ATP) through the activation of specific P2 receptors, which explains why hepatocellular proliferation is markedly lower in immunodeficient mice lacking NK cells compared to wild-type mice after PHx