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Suppression of Cx43 hemichannels via intrathecal injection of blockers such as Gap26, Gap27 or Peptide 5 reduces the production of chemokines CXCL1 and CXCL12, as well as cytokines IL-1β and IL-6, in various neuropathic pain models, including nerve injury, chemotherapy-induced and bone cancer models 496,498,504,505

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Jung, An, Eom, Kang, & Kim, 2017), and Korean red ginseng (Kim et al., 2014)) and active constituents of ginseng (ginsenosides (Baek, Shin, Kim, Chang, & Park, 2017