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We observed that addition of electron-withdrawing substituents on the phenyl ring increased the electrophilicity of the chloroacetamide carbon and improved potency of inhibition (Supplementary Table 1)

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The Impact of a Single Day on Symptoms and the Misconception of B12 Storage B12 Excretion: You are correct that a significant portion of the injected hydroxocobalamin is excreted from the body within 48 hours