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A key characteristic that has allowed researchers to discern between these two complexes is the binding of the FK506‐binding protein 12 (FKBP12) to the macrolide rapamycin, forming a complex that is capable of directly inhibiting mTORC1 (Brown et al., 1994), but not mTORC2 which has thus been deemed to be insensitive to rapamycin (Jacinto et al., 2004)
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