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The ferroptosis-related genes AIFM2 and NFSI were identified in a prostate cancer gene risk model, and in vivo and in vitro experiments showed that knockout of these two genes promotes ferroptosis [55]
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The ε-amino group of Lys 185 acts as a general base, abstracting a proton from the hydroxyl group at C-3 of 6-phosphogluconate
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