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The two rostral burr holes were placed just basal from the posterior interocular line, the two basal burr holes were placed just rostral to the lambdoid suture (and transverse sinuses) on both sides, respectively, and the middle two burr holes were placed in the line between the basal and rostral burr holes

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However, they also have limitations: many are unstable in the gut, so they are often given by injection, and some have limited human data outside of specific indications