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To avoid and manage these problems, one approach is Robert and Szabo’s concept of cytoprotection, which holds innate cell (epithelial (Robert) [41,42,43] endothelial (Szabo) [43,44,45,46,47]) integrity and protection/maintenance/reestablishment in the stomach to be translated to other organ therapy (cytoprotection → organoprotection) [48,49] via the cytoprotection agent’s effect
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Critics correctly point out that animal studies have limitations for predicting human outcomes
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