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It is an acquired inflammatory condition in which fibrous scar tissue and plaques form in the soft tissue of the penis and/or cause a thickening of the tunica albuginea (the fibrous layer of tissue between the two corpora sponges that make up an erection)

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Researchers have noted that its potency in synaptic assays is orders of magnitude greater than brain-derived neurotrophic factor (BDNF), the body's primary natural driver of neuroplasticity