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Interestingly, while the role of GSTs has classically been associated to the modification of small molecules and the role of glutaredoxins to the deglutathionylation of proteins, it has recently been shown that human GSTO1-1 can deglutathionylate Ξ²-actin, which should prompt us to consider proteins as GST substrates (Menon and Board, 2013)
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