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5, 10-Methylene-THF is converted to 5-methyl-THF by the flavoprotein 5,10-methylene-tetrahydrofolate reductase ( MTHFR ) in an irreversible and flavin adenine dinucleotide ( FADH ) and nicotinamide adenine dinucleotide phosphate ( NADPH )-dependent reaction

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Mechanistically, we demonstrated a reduction in apoptosis and necroptosis in lung epithelial cells on inhibition of glutathione reductase