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Treatment protocol The standard sermorelin treatment protocol entails: Five doses per week Nighttime dosages (to coincide with your body’s natural growth hormone release)22 Regular laboratory testing to track your body’s response (e.g., whether your IGF-1 levels are increasing) While the onset of effects may vary depending on various factors — age, body mass, desired health outcomes — sermorelin treatment generally follows a three-part timeline: Initiation: In the first 1-4 weeks, your physician monitors your tolerance and response to the medication