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MK-677 Side Effects The results of a study into the effects of MK-677 on healthy, older adults showed that it causes the following side effects [13]: Increased fasting blood glucose levels (0.3 mmol/L, 5 mg/dL on average) Decreased insulin sensitivity Increased appetite (typically subsides within a few months) Transient, mild lower extremity edema and muscle pain Decreased low density lipoprotein cholesterol Increased cortisol levels This is consistent with the results of other MK-677 human clinical trials to date, which have not linked the compound to any severe side effects