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These results support development of small molecule NNMT inhibitors as therapeutics to reverse diet-induced obesity and validate NNMT as a viable target to treat obesity and related metabolic conditions
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Mice were initially group housed (three/cage) and allowed to acclimate to the colony environment maintained at a constant temperature (21–23°C) and humidity (40–50%) on a 12-hour light-dark cycle (lights on 0600–1800 h)
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