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GSH appears to be involved in the crosstalk between ferroptosis and autophagy

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Iron plays a direct and causal role in the pathogenesis of diabetes mediated by β-Cell exhaustion and insulin resistance (Simcox and McClain, 2013), even in the absence of apparent iron overload (Vari et al., 2007), thus precise control of iron levels in the body is critical for maintaining metabolic homeostasis (Wang et al., 2021)