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Folic acid and 5-methyl-THF in aqueous solutions are photostable in the absence of oxygen 106,337,340,356,357,358

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Covalent targeting of noncatalytic cysteine residues at the ATP-binding site of kinases has since proven to be a successful approach to overcome competition by the native substrate [9,10], as illustrated by clinically approved covalent Bruton’s Tyrosine Kinase (BTK) inhibitors [11,12,13] and covalent (mutant) EGFR inhibitors [14,15,16,17]