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Discontinuation rates and adverse event burdens in cagrisema were higher than semaglutide monotherapy Extrapolating from cagrisema to a hypothetical retatrutide-cagrilintide combination: the marginal benefit of adding cagrilintide to retatrutide might be modest (a few percentage points of additional weight loss), and the tolerability burden might be substantial

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Oral capsules are a more convenient format but almost certainly deliver less intact peptide systemically