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If you’re DIYing or shopping around, look for “Aloe Barbadensis Leaf Juice” as the first or second ingredient —and watch out for anything that lists alcohol, fragrance, or colorants in the top half of the list.

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Conversely, individuals with mutations undermining the generation of PE phospholipids present with severe hereditary spastic paraplegias and white matter pathology, as seen with loss-of-function mutations in SELENOI 166 , 167 and PCYT2 , 168 which are necessary for de novo synthesis of PE phospholipids (Figure 4E)