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The FDA noted that the firm’s post-inspection response described new smoke studies and corrective actions but failed to include the actual protocols or completed studies as supporting documentation
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Co-administration of probenecid increases plasma penicillin concentration by inhibiting elimination via the SLC organic anion transporters 1 and 3 (OAT1/ SLC22A6 and OAT3/ SLC22A8 ) in the kidney [41]
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