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4E, bottom panel) revealed strong enrichment of glycine and serine metabolism, arginine and proline metabolism, the urea cycle, the Warburg effect, alanine metabolism, aspartate metabolism, glutamate metabolism, and methionine metabolism, with additional overrepresentation in pathways linked to nucleotide metabolism, gluconeogenesis, the pentose phosphate pathway, and pyruvate metabolism

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A regular Western Diet provides about 3 g of glycine per day while the endogenous synthesis rate is estimated to generate approximately 1.5–3 g per day (Melendez-Hevia et al., 2009)