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However, it is generally considered beneficial and should not be treated but close observation is recommended.31 No allergic effects against OHCbl were seen in a study 41 at dosages below 2.5 gm although higher dosages from 5 g to 7.5g showed effects in few volunteers ranging from itching, facial erythema, swelling, eye reddening, shivering, dyspnoea, facial oedema and spontaneous exanthema