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Diazeniumdiolate mediated nitrosative stress alters nitric oxide homeostasis through intracellular calcium and S-glutathionylation of nitric oxide synthetase

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Taken together, studies show the critical involvement of lysosomes in the occurrence and development of cardiovascular diseases, which has been confirmed by their decreased number and significant dysfunction, as well as an impaired autophagic process, leading to aberrant cellular responses and even cell death