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Intramuscular (IM): Occasionally utilized when studies specifically target direct skeletal muscle uptake, as skeletal muscle is the primary target organ for MOTS-C’s AMPK-activating effects.² Study Duration MOTS-C research generally follows sub-acute to longitudinal timelines to accurately track metabolic remodeling: Acute/Exercise Models: 2 to 6 weeks is the standard timeline for observing initial shifts in physical endurance, exercise capacity, and immediate glucose clearance rates