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Additionally, it downregulates SLC7A11 channel protein expression while upregulating ALOX3, further promoting ferroptosis ( Multiple studies have also revealed that Saikosaponin A can induce ferroptosis in hepatocellular carcinoma (HCC) cells, both in laboratory settings and in living organisms

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Mice deficient in BACE1 the Alzheimer's [beta]-secretase have normal phenotype and abolished [beta]-amyloid generation