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The most notable peer-reviewed study involving NAD+ iontophoresis patches to date is Pilot Study on Post-COVID Fatigue: A recent pilot study (NCT04604704, published in 2024) assessed the effectiveness of a combination therapy— low-dose naltrexone (LDN) taken orally and NAD+ administered via iontophoresis patches —in patients experiencing persistent moderate/severe fatigue after COVID-19 (Long COVID)