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When adverse effects occurred, they were typically mild and transient, with the most common being mild to moderate headaches (similar frequency to placebo groups), minor injection site reactions (redness, slight swelling), and gastrointestinal effects at higher oral doses (nausea, diarrhea)

GHK

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Physical disruption of the stratum corneum using microneedle arrays has been shown to significantly increase GHK-Cu delivery to the dermis