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It promotes HIF-1α acetylation and degradation by increasing ac-HIF-1α levels, thereby blocking VEGF/VEGFR2 transcription

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4.1.2 Butyrate Butyrate, a frequently encountered SCFA, possesses various functions such as safeguarding the integrity of the BBB, exhibiting anti-inflammatory properties, and preventing apoptosis (Tran and Mohajeri, 2021)