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Bilirubin, a brown pigment produced by heme metabolism, overloads hepatic detoxification pathways, and also accumulates in plasma and tissues, causing jaundice

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Interestingly, it has been reported, that especially some glioma cells, that were therapy-resistent to current treatments, are characterized by increased synthesis of polyunsaturated fats (102) – a dependency that can be readily exploited by GPx4 inhibitors (103)