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Unambiguously, the main diseases produced by excessive lipid peroxidation range from neurodegenerative diseases (manifesting as Alzheimer’s disease (AD), Parkinson’s disease (PD) and others), cardiovascular diseases (manifesting as atherosclerosis, ischemia and heart failure), autoimmune disorders, cancer, kidney and respiratory disease, and other inflammatory and immunological disorders (Ramana et al., 2019)

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It prefers to form Michael-type adducts with cysteine residues due to its highly polarizable, conjugated π-electron system [94]