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In yeast, only the MTase domain is important for Bud23 activity in 40S synthesis (White et al., 2008)

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The GSSG/GSH ratio is the best cellular oxidative stress biomarker, and its increase – which was seen to be greater in the diabetic patients with poor metabolic control – could reflect greater GSH degradation in redox reactions, at the expense of a lesser synthesis.14 Reduced glutathione is an ubiquitous tripeptide that constitutes the main non-enzymatic antioxidant agent in the body, protecting the cells from free radical-induced damage